Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms and therapeutic targets in pediatric brain tumors.
Brain tumors are among the leading causes of cancer-related deaths in children. Although surgery, aggressive radiation, and chemotherapy have improved outcomes, many patients still die of their disease. Moreover, those who survive often suffer devastating long-term side effects from the therapies. A greater understanding of the molecular underpinnings of these diseases will drive the developmen...
متن کاملMetastatic brain tumors: current therapeutic options and historical perspective.
Metastatic brain tumors affect more than 150,000 patients annually in the United States. The therapeutic paradigms for these tumors have evolved over the years and currently encompass numerous modalities implemented by treating physicians across several medical disciplines. The armamentarium of brain tumor treatment involves neurosurgical intervention, whole-brain and focused radiation modaliti...
متن کاملPediatric Brain Tumors
Primitive neuroectodermal tumors (PNET) of the brain include medulloblastoma (MB) and central nervous system primitive neuroectodermal tumor (CNS PNET) subtypes, which share histological features yet differ at the genomic level and in clinical outcome. Delineation of the genetic anomalies between PNET subtypes is a current challenge for establishing effective targeted therapeutic strategies aga...
متن کاملBrain Tumors: Challenges and Opportunities to Cure.
Tumors of the CNS are among the most challenging malignancies to treat. Despite surgery, radiation, and chemotherapy, many patients have incurable cancers and suffer disabling symptoms. The median survival of patients with glioblastoma, the most common malignant adult brain tumor, remains less than 2 years, and brain tumors include the most common and difficult-to-treat malignancies in children...
متن کاملImmunotherapy for Pediatric Brain Tumors
Malignant brain tumors are the most common cause of solid cancer death in children. New targeted therapies are vital to improve treatment outcomes, but must be developed to enable trafficking across the blood brain barrier (BBB). Since activated T cells cross the BBB, cancer immunotherapy can be harnessed to unlock the cytotoxic potential of the immune system. However, standard of care treatmen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pediatric Hematology/Oncology
سال: 2016
ISSN: 1077-4114
DOI: 10.1097/mph.0000000000000551